Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction.

ABSTRACT: Precise control of messenger RNA (mRNA) processing and abundance are increasingly being recognized as critical for proper spatiotemporal gene expression, particularly in neurons. These regulatory events are governed by a large number of trans-acting factors found in neurons, most notably RNA-binding proteins (RBPs) and micro-RNAs (miRs), which bind to specific cis-acting elements or structures within mRNAs. Through this binding mechanism, trans-acting factors, particularly RBPs, control all aspects of mRNA metabolism, ranging from altering the transcription rate to mediating mRNA degradation. In this context the best-characterized neuronal RBP, the Hu/ELAVl family member HuD, is emerging as a key component in multiple regulatory processes--including pre-mRNA processing, mRNA stability, and

SUBMITTER: Bronicki LM 

PROVIDER: S-EPMC3708524 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature