Altered functional connectivity of the insular cortex across prefrontal networks in cocaine addiction.

ABSTRACT: Interoception is theorized to be an important process mediating substance use disorders, and the insular cortex is recognized as a core neural region supporting interoception. The purpose of this study was to compare the integration of the insular cortex into prefrontal-related resting-state networks between individuals with cocaine dependence and healthy controls. Participants comprised 41 patients with cocaine dependence and 19 controls who underwent a resting-state 3-T functional magnetic resonance imaging scan. Individuals with cocaine dependence demonstrated altered functional connectivity of the insular cortex, predominantly the right insular cortex, with all eight prefrontal-related resting-state networks identified through Independent Component Analysis (ICA). A conjunction analysi

SUBMITTER: Cisler JM 

PROVIDER: S-EPMC3708551 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature