Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial.

ABSTRACT:

Background

Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer.

Methods

Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed.

Results

Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses (P=0.01 and P=0.03, respectively).

Conclusion

Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-speci

SUBMITTER: Seebacher V 

PROVIDER: S-EPMC3708572 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature