Markers of systemic inflammation predict survival in patients with advanced renal cell cancer.

ABSTRACT:

Background

The host inflammatory response has a vital role in carcinogenesis and tumour progression. We examined the prognostic value of inflammatory markers (albumin, white-cell count and its components, and platelets) in pre-treated patients with advanced renal cell carcinoma (RCC).

Methods

Using data from a randomised trial, multivariable proportional hazards models were generated to examine the impact of inflammatory markers and established prognostic factors (performance status, calcium, and haemoglobin) on overall survival (OS). We evaluated a new prognostic classification incorporating additional information from inflammatory markers.

Results

Of the 416 patients, 362 were included in the analysis. Elevated neutrophil counts, elevated platelet counts, and a high

SUBMITTER: Fox P 

PROVIDER: S-EPMC3708579 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature