Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?

ABSTRACT: Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer's disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional con

SUBMITTER: Voss MW 

PROVIDER: S-EPMC3708614 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature