Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.

ABSTRACT:

Background

The identification of gene by environment (GxE) interactions has emerged as a challenging but essential task to fully understand the complex mechanism underlying multifactorial diseases. Until now, GxE interactions have been investigated by candidate approaches examining a small number of genes, or agnostically at the genome wide level.

Presentation of the hypothesis

In this paper, we propose a gene selection strategy for investigation of gene-environment interactions. This strategy integrates the information on biological processes shared by genes, the canonical pathways to which they belong and the biological knowledge related to the environment in the gene selection process. It relies on both bioinformatics resources and biological expertise.

Testing the hyp

SUBMITTER: Rava M 

PROVIDER: S-EPMC3708788 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature