Alpha tubulin genes from Leishmania braziliensis: genomic organization, gene structure and insights on their expression.

ABSTRACT:

Background

Alpha tubulin is a fundamental component of the cytoskeleton which is responsible for cell shape and is involved in cell division, ciliary and flagellar motility and intracellular transport. Alpha tubulin gene expression varies according to the morphological changes suffered by Leishmania in its life cycle. However, the objective of studying the mechanisms responsible for the differential expression has resulted to be a difficult task due to the complex genome organization of tubulin genes and to the non-conventional mechanisms of gene regulation operating in Leishmania.

Results

We started this work by analyzing the genomic organization of α-tubulin genes in the Leishmania braziliensis genome database. The genomic organization of L. braziliensis α-tubulin genes di

SUBMITTER: Ramirez CA 

PROVIDER: S-EPMC3708823 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature