Oral neutrophil transcriptome changes result in a pro-survival phenotype in periodontal diseases.

ABSTRACT:

Background

Periodontal diseases are inflammatory processes that occur following the influx of neutrophils into the periodontal tissues in response to the subgingival bacterial biofilm. Current literature suggests that while neutrophils are protective and prevent bacterial infections, they also appear to contribute to damage of the periodontal tissues. In the present study we compare the gene expression profile changes in neutrophils as they migrate from the circulation into the oral tissues in patients with chronic periodontits and matched healthy subjects. We hypothesized that oral neutrophils in periodontal disease patients will display a disease specific transcriptome that differs from the oral neutrophil of healthy subjects.

Methods

Venous blood and oral rinse samples we

SUBMITTER: Lakschevitz FS 

PROVIDER: S-EPMC3708893 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature