Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection.

ABSTRACT: Brain abscesses arise following parenchymal infection with pyogenic bacteria and are typified by inflammation and edema, which frequently results in a multitude of long-term health problems. The impact of adaptive immunity in shaping continued innate responses during late-stage brain abscess formation is not known but is important, because robust innate immunity is required for effective bacterial clearance. To address this issue, brain abscesses were induced in TCR αβ knockout (KO) mice, because CD4(+) and NKT cells represented the most numerous T cell infiltrates. TCR αβ KO mice exhibited impaired bacterial clearance during later stages of infection, which was associated with alterations in neutrophil and macrophage recruitment, as well as perturbations in cytokine/chemokine expression.

SUBMITTER: Holley MM 

PROVIDER: S-EPMC3709259 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature