Ontology highlight
ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC3709448 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Kim Jung Hwan JH Wang Xin X Coolon Rosemary R Ye Bing B
Neuron 20130601 5
Expression of the Down syndrome cell-adhesion molecule (Dscam) is increased in the brains of patients with several neurological disorders. Although Dscam is critically involved in many aspects of neuronal development, little is known about either the mechanism that regulates its expression or the functional consequences of dysregulated Dscam expression. Here, we show that Dscam expression levels serve as an instructive code for the size control of presynaptic arbor. Two convergent pathways, invo ...[more]