Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.

ABSTRACT: The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin desquamation and semen liquefaction, and work by a large number of investigators has elucidated pairwise and autolytic activation relationships among the KLKs with the potential for more extensive activation cascades. More recent work has asked whether functional intersection of KLKs with other types of regulatory prote

SUBMITTER: Yoon H 

PROVIDER: S-EPMC3709557 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature