Arginine deiminase inhibits Porphyromonas gingivalis surface attachment.

ABSTRACT: The oral cavity is host to a complex microbial community whose maintenance depends on an array of cell-to-cell interactions and communication networks, with little known regarding the nature of the signals or mechanisms by which they are sensed and transmitted. Determining the signals that control attachment, biofilm development and outgrowth of oral pathogens is fundamental to understanding pathogenic biofilm development. We have previously identified a secreted arginine deiminase (ADI) produced by Streptococcus intermedius that inhibited biofilm development of the commensal pathogen Porphyromonas gingivalis through downregulation of genes encoding the major (fimA) and minor (mfa1) fimbriae, both of which are required for proper biofilm development. Here we report that this inhibitory eff

SUBMITTER: Cugini C 

PROVIDER: S-EPMC3709564 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature