Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma.

ABSTRACT: Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the present study, we analyzed combined genomewide DNA methylation and gene expression data of patients treated in the Medical Research Council Myeloma IX trial. We used these data to identify epigenetically repressed tumor suppressor genes with prognostic relevance in myeloma. We identified 195 genes with changes in methylation status that were significantly associated with prognosis. Combining DNA methylation and gene expression data led to the identification of the epigenetically regulated tumor modulating genes GPX3, RBP1, SPARC, and TGFBI. Hypermethylation of these genes was associated with si

SUBMITTER: Kaiser MF 

PROVIDER: S-EPMC3709654 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature