Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis.

ABSTRACT:

Objective

To systematically review the literature on human gene expression data of placental tissue in pre-eclampsia and to characterize a meta-signature of differentially expressed genes in order to identify novel putative diagnostic markers.

Data sources

Medline through 11 February 2011 using MeSH terms and keywords related to placenta, gene expression and gene expression arrays; GEO database using the term "placent*"; and reference lists of eligible primary studies, without constraints.

Methods

From 1068 studies retrieved from the search, we included original publications that had performed gene expression array analyses of placental tissue in the third trimester and that reported on differentially expressed genes in pre-eclampsia versus normotensive controls. Two

SUBMITTER: Kleinrouweler CE 

PROVIDER: S-EPMC3709893 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature