Simplified method for predicting a functional class of proteins in transcription factor complexes.

ABSTRACT:

Background

Initiation of transcription is essential for most of the cellular responses to environmental conditions and for cell and tissue specificity. This process is regulated through numerous proteins, their ligands and mutual interactions, as well as interactions with DNA. The key such regulatory proteins are transcription factors (TFs) and transcription co-factors (TcoFs). TcoFs are important since they modulate the transcription initiation process through interaction with TFs. In eukaryotes, transcription requires that TFs form different protein complexes with various nuclear proteins. To better understand transcription regulation, it is important to know the functional class of proteins interacting with TFs during transcription initiation. Such information is not fully avail

SUBMITTER: Piatek MJ 

PROVIDER: S-EPMC3709904 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature