Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study.

ABSTRACT:

Background

The rs41318021 polymorphism in the SLC7A1 gene affects endothelial NO production through changes in L-arginine transport. This variation could thus hypothetically cause dysfunction of endothelium and lead to hypertension. The association of rs41318021 with hypertension was therefore studied in a Finnish cohort.

Methods

A total of 412 hypertensive cases and 771 non-hypertensive controls from a Finnish 50-year-old cohort were included in this study. The data was collected from the Tampere adult population cardiovascular risk study (TAMRISK). DNA was extracted from buccal swabs and amplified using PCR. A subpopulation of men and women who had available follow-up data of blood pressure measurements at the age of 35-, 40-, 45- and 50 years was also analyzed.

Results

SUBMITTER: Maatta K 

PROVIDER: S-EPMC3710090 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature