Project description:The reason why prostate cancer is significantly more common in Western than Asian men is unknown. Using a genome-wide approach to compare the genomic changes in prostate cancer tissues, we determined that those from Chinese patients lack key somatic genomic changes commonly found in Western patients, including the 21q22.2-22.3 deletion which causes the TMPRSS2:ERG fusion gene, and 10q deletion which leads to PTEN inactivation. The results were confirmed and their consequence on ERG expression was identified by study of a large series of Chinese and UK samples using tissue-microarrays. Subsequently, we identified significant AR genotype differences between UK and Chinese prostate cancer patients. The identification of specific somatic genomic differences in cancers from distinct populations may provide an opportunity to identify cancer-causing or protective factors.

2010-05-15 | GSE18333 | GEO

Colon Cancer Study of Fecal Samples in Shanghai, China

Project description:Background: - Early detection of colon cancer can improve the chances of successful treatment for most people. This approach is especially important if blood is detected in the stool. However, much better stool sample tests are needed to find this cancer early. To improve the tests, researchers want to collect samples from people who are already being screened for colon cancer. This study will collect information and samples from older adults in Shanghai, China. These adults will be participating in screening tests for colon cancer. Objectives: - To collect samples and medical information for colon cancer screening from older adults in Shanghai, China. Eligibility: * Adults between 50 and 74 years of age who are being screened for colon cancer. * Participants will be recruited from two community health centers in Shanghai, China. Design: * Participants will provide information on their medical history and factors related to colon cancer. They will respond to questions on use of medications, diet choices (such as eating red meat), bowel habits, and other factors. * Participants will collect samples for study. These samples will be collected within 3 days of the screening visit. Particpants will provide a urine sample and four stool samples. They will also use cotton swabs to collect samples from just inside the anus. The samples will be returned to the study doctors for research tests that may indicate who has colon cancer. * Treatment will not be provided as part of this study.

| 2139076 | ecrin-mdr-crc

Health status of aged women with or without the experience of practicing yoga.

Project description: Not available

| S-EPMC10552255 | biostudies-literature

Experience and expression of postnatal mothers practicing kangaroo mother care: A qualitative study.

Project description: Not available

| S-EPMC11418303 | biostudies-literature

A Thematic Inquiry into the Burnout Experience of Australian Solo-Practicing Clinical Psychologists.

Project description: Not available

| S-EPMC5785720 | biostudies-literature