A genome-wide integrative study of microRNAs in human liver.

ABSTRACT:

Background

Recent studies have illuminated the diversity of roles for microRNAs in cellular, developmental, and pathophysiological processes. The study of microRNAs in human liver tissue promises to clarify the therapeutic and diagnostic value of this important regulatory mechanism of gene expression.

Results

We conducted genome-wide profiling of microRNA expression in liver and performed an integrative analysis with previously collected genotype and transcriptome data. We report here that the Very Important Pharmacogenes (VIP Genes), comprising of genes of particular relevance for pharmacogenomics, are under substantial microRNA regulatory effect in the liver. We set out to elucidate the genetic basis of microRNA expression variation in liver and mapped microRNA expression

SUBMITTER: Gamazon ER 

PROVIDER: S-EPMC3710218 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature