Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection.

ABSTRACT:

Background

Enterovirus 71 (EV71) infections are associated with a high prevalence of hand, foot and mouth disease (HFMD) in children and occasionally cause lethal complications. Most infections are self-limiting. However, resulting complications, including aseptic meningitis, encephalitis, poliomyelitis-like acute flaccid paralysis, and neurological pulmonary edema or hemorrhage, are responsible for the lethal symptoms of EV71 infection, the pathogenesis of which remain to be clarified.

Results

In the present study, 2-week-old Institute of Cancer Research (ICR) mice were infected with a mouse-adapted EV71 strain. These infected mice demonstrated progressive paralysis and died within 12 days post infection (d.p.i.). EV71, which mainly replicates in skeletal muscle tissues, ca

SUBMITTER: Xiu JH 

PROVIDER: S-EPMC3710232 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature