Life-threatening gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: a case report.

ABSTRACT:

Background

Temsirolimus has important clinical activity in both untreated and previously treated patients with advanced renal cell carcinoma. Targeted therapy-related stomatitis and mucositis have occurred during targeted therapies, but there is no consensus on which strategy is the most effective. We herein report a case in which several sessions of endoscopic hemostasis with argon plasma coagulation (APC) effectively resolved life-threatening gastrointestinal bleeding that had occurred during targeted therapy. This is the first case report of such an adverse drug reaction in the literature.

Case presentation

A 47-year-old female patient with advanced renal cell carcinoma was treated with temsirolimus. Eight weeks after starting targeted therapy, the patient was admitted to

SUBMITTER: Fujihara S 

PROVIDER: S-EPMC3710497 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature