Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy.

ABSTRACT:

Purpose

To evaluate the prognostic utility of the cell cycle progression (CCP) score, a RNA signature based on the average expression level of 31 CCP genes, for predicting biochemical recurrence (BCR) in men with prostate cancer treated with external beam radiation therapy (EBRT) as their primary curative therapy.

Methods and materials

The CCP score was derived retrospectively from diagnostic biopsy specimens of men diagnosed with prostate cancer from 1991 to 2006 (n=141). All patients were treated with definitive EBRT; approximately half of the cohort was African American. Outcome was time from EBRT to BCR using the Phoenix definition. Median follow-up for patients without BCR was 4.8 years. Association with outcome was evaluated by Cox proportional hazards survival analysi

SUBMITTER: Freedland SJ 

PROVIDER: S-EPMC3710548 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature