Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.

ABSTRACT: The Mamu-A, Mamu-B, and Mamu-DRB genes of the rhesus macaque show several levels of complexity such as allelic heterogeneity (polymorphism), copy number variation, differential segregation of genes/alleles present on a haplotype (diversity) and transcription level differences. A combination of techniques was implemented to screen a large panel of pedigreed Indian rhesus macaques (1,384 individuals representing the offspring of 137 founding animals) for haplotype diversity in an efficient and inexpensive manner. This approach allowed the definition of 140 haplotypes that display a relatively low degree of region variation as reflected by the presence of only 17 A, 18 B and 22 DRB types, respectively, exhibiting a global linkage disequilibrium comparable to that in humans. This finding contr

SUBMITTER: Doxiadis GG 

PROVIDER: S-EPMC3710572 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature