Low voltage vagal nerve stimulation reduces bronchoconstriction in guinea pigs through catecholamine release.

ABSTRACT:

Objective

  Electrical stimulation of the vagus nerve at relatively high voltages (e.g., >10 V) can induce bronchoconstriction. However, low voltage (≤2 V) vagus nerve stimulation (VNS) can attenuate histamine-invoked bronchoconstriction. Here, we identify the mechanism for this inhibition.

Methods

  In urethanea-nesthetized guinea pigs, bipolar electrodes were attached to both vagus nerves and changes in pulmonary inflation pressure were recorded in response to i.v. histamine and during VNS. The attenuation of the histamine response by low-voltage VNS was then examined in the presence of pharmacologic inhibitors or nerve ligation.

Results

  Low-voltage VNS attenuated histamine-induced bronchoconstriction (4.4 ± 0.3 vs. 3.2 ± 0.2 cm H(2) O, p < 0.01) and remained effe

SUBMITTER: Hoffmann TJ 

PROVIDER: S-EPMC3710689 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature