BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

ABSTRACT: Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regulators to stabilize lineage commitment. Genetic polymorphisms within a single locus encoding the transcription factor BACH2 are associated with numerous autoimmune and allergic diseases including asthma, Crohn's disease, coeliac disease, vitiligo, multiple sclerosis and type 1 diabetes. Although these associations point to a shared mechanism underlying susceptibility to diverse immune-mediated diseases, a function for BACH2 in the maintenance of immune homeostasis has not been e

SUBMITTER: Roychoudhuri R 

PROVIDER: S-EPMC3710737 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature