Ontology highlight
ABSTRACT:
SUBMITTER: Post A
PROVIDER: S-EPMC3710801 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Post Anneke A Pannekoek Willem-Jan WJ Ross Sarah H SH Verlaan Ingrid I Brouwer Patricia M PM Bos Johannes L JL
Proceedings of the National Academy of Sciences of the United States of America 20130624 28
Rap1 is a small GTPase regulating cell-cell adhesion, cell-matrix adhesion, and actin rearrangements, all processes dynamically coordinated during cell spreading and endothelial barrier function. Here, we identify the adaptor protein ras-interacting protein 1 (Rasip1) as a Rap1-effector involved in cell spreading and endothelial barrier function. Using Förster resonance energy transfer, we show that Rasip1 interacts with active Rap1 in a cellular context. Rasip1 mediates Rap1-induced cell spread ...[more]