Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model.

ABSTRACT:

Background & aims

Sinusoidal obstruction syndrome (SOS) following oxaliplatin based chemotherapy can have a significant impact on post-operative outcome following resection of colorectal liver metastases. To date no relevant experimental models of oxaliplatin induced SOS have been described. The aim of this project was to establish a rodent model which could be utilised to investigate mechanisms underlying SOS to aid the development of therapeutic strategies.

Methods

C57Bl/6 mice, maintained on a purified diet, were treated with intra-peritoneal FOLFOX (n=10), or vehicle (n=10), weekly for five weeks and culled one week following final treatment. Sections of the liver and spleen were fixed in formalin and paraffin embedded for histological analysis. The role of oxidative str

SUBMITTER: Robinson SM 

PROVIDER: S-EPMC3710969 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature