Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

ABSTRACT: Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.

SUBMITTER: Majmudar CY 

PROVIDER: S-EPMC3711073 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature