Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.

ABSTRACT: The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.

SUBMITTER: Kuil J 

PROVIDER: S-EPMC3711080 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature