Cost-effectiveness of cardiac resynchronization therapy in the MADIT-CRT trial.

ABSTRACT:

Background

The Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) trial demonstrated that cardiac resynchronization therapy (CRT) when added to the implantable cardiac defibrillator (ICD) reduces risk of heart failure or death in minimally symptomatic patients with reduced cardiac ejection fraction and wide QRS complex.

Objectives

To evaluate 4-year cost-effectiveness of CRT-ICD compared to ICD alone using MADIT-CRT data.

Research design

Patients enrolled in the trial were randomized to implantation of either ICD or CRT-ICD in a 2:3 ratio, with up to 4-year follow-up period. Cost-effectiveness analyses were conducted, and sensitivity analyses by age, gender, and left bundle branch block (LBBB) conduction pattern were p

SUBMITTER: Noyes K 

PROVIDER: S-EPMC3711178 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature