Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence.

ABSTRACT:

Objective

In the present study, we scanned the whole exome in three independent samples to search for replicable risk nonsynonymous (ns) variants (ns single-nucleotide polymorphisms [nsSNPs]) for alcohol dependence.

Method

A total of 10,554 subjects in three independent samples were analyzed for association with alcohol dependence, including one European American sample (1,409 cases with alcohol dependence and 1,518 controls), one African American sample (681 cases and 508 controls), and one European Australian sample (a total of 6,438 family subjects with 1,645 alcohol-dependent probands). RNA expression of the risk genes in human, mouse, and rat brains was also explored.

Results

We identified a total of 70 nsSNPs at 65 genes with nominally replicable associations; 2

SUBMITTER: Zuo L 

PROVIDER: S-EPMC3711352 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature