Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation.

ABSTRACT:

Background

Mycophenolate-related anemia and leukopenia are well-known toxicities after transplantation. Toxicity leads to dose reduction, addition of colony-stimulating factors or erythropoietin, or discontinuation of immunosuppressive therapy. The causes of and risk factors associated with toxicity are unclear.

Methods

We studied the association between mycophenolate-related anemia and leukopenia and 2724 single nucleotide polymorphisms (SNP) in 978 patients undergoing living or deceased donor kidney transplant. Patients were followed up to time of first anemia (hemoglobin<10 gm/dL or hematocrit<30%) or first leukopenia (white blood cell [WBC] count <3000 cells/mm), which required clinical intervention in the first 6 months after transplant.

Results

Anemia occurred i

SUBMITTER: Jacobson PA 

PROVIDER: S-EPMC3711617 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature