Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast.

ABSTRACT:

Background

Most quantitative measures of phenotypic traits represent macroscopic contributions of large numbers of cells. Yet, cells of a tissue do not behave similarly, and molecular studies on several organisms have shown that regulations can be highly stochastic, sometimes generating diversified cellular phenotypes within tissues. Phenotypic noise, defined here as trait variability among isogenic cells of the same type and sharing a common environment, has therefore received a lot of attention. Given the potential fitness advantage provided by phenotypic noise in fluctuating environments, the possibility that it is directly subjected to evolutionary selection is being considered. For selection to act, phenotypic noise must differ between contemporary genotypes. Whether this is t

SUBMITTER: Yvert G 

PROVIDER: S-EPMC3711934 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature