Relating genes to function: identifying enriched transcription factors using the ENCODE ChIP-Seq significance tool.

ABSTRACT:

Motivation

Biological analysis has shifted from identifying genes and transcripts to mapping these genes and transcripts to biological functions. The ENCODE Project has generated hundreds of ChIP-Seq experiments spanning multiple transcription factors and cell lines for public use, but tools for a biomedical scientist to analyze these data are either non-existent or tailored to narrow biological questions. We present the ENCODE ChIP-Seq Significance Tool, a flexible web application leveraging public ENCODE data to identify enriched transcription factors in a gene or transcript list for comparative analyses.

Implementation

The ENCODE ChIP-Seq Significance Tool is written in JavaScript on the client side and has been tested on Google Chrome, Apple Safari and Mozilla Firefox br

SUBMITTER: Auerbach RK 

PROVIDER: S-EPMC3712221 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature