The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases.

ABSTRACT: The families of protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) function in a coordinated manner to regulate signal transduction events that are critical for cellular homeostasis. Aberrant tyrosine phosphorylation, resulting from disruption of either PTP or PTK function, has been shown to be the cause of major human diseases, including cancer and diabetes. Consequently, the characterization of small-molecule inhibitors of these kinases and phosphatases may not only provide molecular probes with which to define the significance of particular signaling events, but also may have therapeutic implications. BAY-11-7082 is an anti-inflammatory compound that has been reported to inhibit IκB kinase activity. The compound has an α,β-unsaturated electrophilic center, which co

SUBMITTER: Krishnan N 

PROVIDER: S-EPMC3712534 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature