Role of complement cascade in abdominal aortic aneurysms.

ABSTRACT:

Objective

The goal of this study was to investigate the role of complement cascade genes in the pathobiology of human abdominal aortic aneurysms (AAAs).

Methods and results

Results of a genome-wide microarray expression profiling revealed 3274 differentially expressed genes between aneurysmal and control aortic tissue. Interestingly, 13 genes in the complement cascade were significantly differentially expressed between AAA and the controls. In silico analysis of the promoters of the 13 complement cascade genes showed enrichment for transcription factor binding sites for signal transducer and activator of transcription (STAT)5A. Chromatin-immunoprecipitation experiments demonstrated binding of transcription factor STAT5A to the promoters of the majority of the complement casc

SUBMITTER: Hinterseher I 

PROVIDER: S-EPMC3712630 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature