Annotating cancer variants and anti-cancer therapeutics in reactome.

ABSTRACT: Reactome describes biological pathways as chemical reactions that closely mirror the actual physical interactions that occur in the cell. Recent extensions of our data model accommodate the annotation of cancer and other disease processes. First, we have extended our class of protein modifications to accommodate annotation of changes in amino acid sequence and the formation of fusion proteins to describe the proteins involved in disease processes. Second, we have added a disease attribute to reaction, pathway, and physical entity classes that uses disease ontology terms. To support the graphical representation of "cancer" pathways, we have adapted our Pathway Browser to display disease variants and events in a way that allows comparison with the wild type pathway, and shows connections bet

SUBMITTER: Milacic M 

PROVIDER: S-EPMC3712731 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature