VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians.

ABSTRACT: The VKORC1 Asp36Tyr single nucleotide polymorphism (SNP) is one of the most promising predictors of high warfarin dose, but data on its population prevalence is incomplete. We determined the frequency of this SNP in participants from seven countries on four continents and investigated its effect on warfarin dose requirement. One thousand samples were analysed to define the population prevalence of this SNP. Those samples included individuals from Egypt, Ghana, Sudan, Kenya, Saudi Arabia, Peru and African Americans from the United States. A total of 206 Egyptian samples were then used to investigate the effect of this SNP on warfarin dose requirements. This SNP was most frequent among Kenyans and Sudanese, with a minor allele frequency (MAF) of 6% followed by Saudi Arabians and Egyptians wi

SUBMITTER: Shahin MH 

PROVIDER: S-EPMC3712827 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature