Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL.

ABSTRACT: Lytic granule exocytosis is the major pathway used by CD8+ CTL to kill virally infected and tumor cells. Despite the obvious importance of this pathway in adaptive T cell immunity, the molecular identity of enzymes involved in the regulation of this process is poorly characterized. One signal known to be critical for the regulation of granule exocytosis-mediated cytotoxicity in CD8+ T cells is Ag receptor-induced activation of protein kinase C (PKC). However, it is not known which step of the process is regulated by PKC. In addition, it has not been determined to date which of the PKC family members is required for the regulation of lytic granule exocytosis. By combination of pharmacological inhibitors and use of mice with targeted gene deletions, we show that PKCdelta is required for gran

SUBMITTER: Ma JS 

PROVIDER: S-EPMC3712856 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature