Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress responses.

ABSTRACT:

Background

Zymomonas mobilis ZM4 is a capable ethanologenic bacterium with high ethanol productivity and ethanol tolerance. Previous studies indicated that several stress-related proteins and changes in the ZM4 membrane lipid composition may contribute to ethanol tolerance. However, the molecular mechanisms of its ethanol stress response have not been elucidated fully.

Methodology/principal findings

In this study, ethanol stress responses were investigated using systems biology approaches. Medium supplementation with an initial 47 g/L (6% v/v) ethanol reduced Z. mobilis ZM4 glucose consumption, growth rate and ethanol productivity compared to that of untreated controls. A proteomic analysis of early exponential growth identified about one thousand proteins, or approximately

SUBMITTER: Yang S 

PROVIDER: S-EPMC3712917 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature