Exploring the adenylation domain repertoire of nonribosomal peptide synthetases using an ensemble of sequence-search methods.

ABSTRACT: The introduction of two-dimension (2D) graphs and their numerical characterization for comparative analyses of DNA/RNA and protein sequences without the need of sequence alignments is an active yet recent research topic in bioinformatics. Here, we used a 2D artificial representation (four-color maps) with a simple numerical characterization through topological indices (TIs) to aid the discovering of remote homologous of Adenylation domains (A-domains) from the Nonribosomal Peptide Synthetases (NRPS) class in the proteome of the cyanobacteria Microcystis aeruginosa. Cyanobacteria are a rich source of structurally diverse oligopeptides that are predominantly synthesized by NPRS. Several A-domains share amino acid identities lower than 20 % being a possible source of remote homologous. Theref

SUBMITTER: Aguero-Chapin G 

PROVIDER: S-EPMC3712989 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature