The effect of race-ethnicity on the comparative effectiveness of clozapine among Medicaid beneficiaries.

ABSTRACT:

Objective

Effectiveness trials have confirmed the superiority of clozapine in schizophrenia treatment, but little is known about whether the drug's superiority holds across racial-ethnic groups. This study examined the effectiveness by race-ethnicity of clozapine relative to other antipsychotics among adult patients in maintenance antipsychotic treatment.

Methods

Black, Latino, and white Florida Medicaid beneficiaries with schizophrenia receiving maintenance treatment with clozapine or other antipsychotics between July 1, 2000, and June 30, 2005, were identified. Cox proportional hazard regression models were used to estimate associations between clozapine and race-ethnicity and their interaction; time to discontinuation for any cause was the primary measure of effectiveness

SUBMITTER: Horvitz-Lennon M 

PROVIDER: S-EPMC3713199 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature