MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects.

ABSTRACT: Menopause is characterized by the rapid age-related decline of circulating 17β-estradiol (E(2)) levels in women, which can sometimes result in cognitive disorders such as impaired memory and increased anxiety. Hormone therapy (HT) is a widely used treatment for the adverse effects associated with menopause; however, evidence suggests that HT administered to postmenopausal women age 65 years and over can lead to increased risks for cognitive disorders. We hypothesized that these age-related changes in E(2) action are due to posttranscriptional gene regulation by microRNAs (miRNAs). miRNAs are a class of small noncoding RNAs that regulate gene expression by binding to the 3'-untranslated region of target mRNAs and subsequently target these transcripts for degradation. In the present study, 3

SUBMITTER: Rao YS 

PROVIDER: S-EPMC3713211 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature