Ontology highlight
ABSTRACT:
SUBMITTER: Franco LM
PROVIDER: S-EPMC3713456 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Franco Luis M LM Bucasas Kristine L KL Wells Janet M JM Niño Diane D Wang Xueqing X Zapata Gladys E GE Arden Nancy N Renwick Alexander A Yu Peng P Quarles John M JM Bray Molly S MS Couch Robert B RB Belmont John W JW Shaw Chad A CA
eLife 20130716
Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody respons ...[more]