Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells.

ABSTRACT:

Background

HIV infection decreases thymic output and induces chronic T-cell activation.

Objective

To examine the reconstitution of naive and activated T cells.

Methods

Extended immune phenotyping of CD4(+) and CD8(+) T-cell subsets was combined with T-cell receptor rearrangement excision circle (TREC) levels and measures of T-cell receptor repertoire perturbations in CD8(+) T-cell subpopulation to define the global effect of HIV-1 on T-cell dynamics. Evaluations before and after therapy were performed in HIV-infected children and compared with those in healthy individuals.

Results

Ten HIV-infected children and adolescents with a broad range of pretherapy CD4(+) T-cell counts were compared with healthy individuals. Pretherapy late activated CD8(+) T cells (CD3(+

SUBMITTER: Yin L 

PROVIDER: S-EPMC3713492 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature