Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial.

ABSTRACT:

Background

Recent evidence suggests that daily aspirin use decreases cancer risk, particularly for colorectal cancer, but evidence for alternate-day use is scant.

Objective

To examine the association between long-term, alternate-day, low-dose aspirin and cancer in healthy women.

Design

Observational follow-up of a randomized trial.

Setting

Female health professionals.

Participants

39,876 women aged 45 years or older in the Women's Health Study (ClinicalTrials.gov: NCT00000479), 33 682 of whom continued observational follow-up.

Intervention

100 mg of alternate-day aspirin or placebo through March 2004, with a median 10-year follow-up. Posttrial follow-up continued through March 2012.

Measurements

Cancer incidence.

Results

A total of 5

SUBMITTER: Cook NR 

PROVIDER: S-EPMC3713531 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature