Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.

ABSTRACT:

Background

ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias.

Methods and results

We performed a genome-wide association study to identify genomic markers of QRS duration in 5272 individuals without cardiac disease selected from electronic medical record algorithms at 5 sites in the Electronic Medical Records and Genomics (eMERGE) network. The most significant loci were evaluated within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium QRS genome-wide association study meta-analysis. Twenty-three single-nucleotide polymorphisms in 5 loci, previously described by CHARGE, were replicated in the eMERGE samples; 18 single-

SUBMITTER: Ritchie MD 

PROVIDER: S-EPMC3713791 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature