Dataset Information

A miR-SNP of the XPO5 gene is associated with advanced non-small-cell lung cancer.

ABSTRACT:

Objectives

MicroRNA (miRNA)-related single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. A miR-SNP of rs11077 located in the 3' untranslated region (3' UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced non-small-cell lung cancer (NSCLC) patients to evaluate its association with cancer outcome.

Materials and methods

The miR-SNP was genotyped with ligase detection reaction method. Survival curves were calculated using the Kaplan-Meier method, and multivariate survival analysis was performed using a Cox proportional hazards model.

Results

The AC genotype of rs11077, which carries C or A allele, was significantly associated with a better chemotherapy response (P = 0.001). In addition, rs11077 was independently associated with overall survival in advanced NSCLC patients through multivariate analysis (relative risk 0.457; 95% confidence interval: 0.251-0.831; P = 0.010).

Conclusion

rs11077 was associated with chemotherapy response and survival of advanced NSCLC patients. The analysis of miR-SNPs in miRNA processing machinery genes can help identify patient subgroups that are at high risk for poor disease outcomes.

SUBMITTER: Ding C

PROVIDER: S-EPMC3713958 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

A miR-SNP of the XPO5 gene is associated with advanced non-small-cell lung cancer.

Ding Cuimin C Li Cuiqiao C Wang Hongjing H Li Bin B Guo Zhanjun Z

OncoTargets and therapy 20130711

<h4>Objectives</h4>MicroRNA (miRNA)-related single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. A miR-SNP of rs11077 located in the 3' untranslated region (3' UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced non-small-cell lung cancer (NSCLC) patients to evaluate its association with cancer outcome.<h4>Materials and methods</h4>The miR-SNP was genotyped with ligase detection rea ...[more]

PMID: 23874110

Similar Datasets

Project description:BackgroundLung cancer is one of the leading causes of death worldwide. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and may act as both tumor suppressors and as oncogenes. The presence of single nucleotide polymorphisms (SNPs) inside the miRNA genomic region could affect target miRNA maturation, expression, and binding to its target mRNA and contribute to cancer development. Previous studies on the SNPs Rs2910164 in miR-146a and Rs767649 in miR-155 showed association with non-small cell lung cancer (NSCLC) development. Thus, the aim of this study was to detect any correlation between those SNPs in Iranian NSCLC patients.MethodsIn a small cohort study, 165 NSCLC patients and 147 noncancer controls were enrolled between Apr 2015 and Sep 2019 at the Masih Daneshvari Hospital, Tehran, Iran. Allele frequencies from the genomic DNA of blood cells were studied using PCR-RFLP and their association with the risk of lung cancer was evaluated.ResultsThe rs2910164C allele (OR = 1.56, 95% CI = 1.10-2.21, p = 0.012) and CC genotype (OR = 2.93, 95% CI = 1.07-7.9, p = 0.034, respectively) were associated with a significantly increased risk for lung cancer compared to that for the GG genotype. When patients were stratified according to smoking exposure, no association with rs2910164 variants was found. The AT genotype (OR = 0.57, 95% CI = 0.33-0.99, p = 0.048) and the A allele frequency (OR = 0.58, 95% CI = 0.35-0.98, p = 0.043) in rs767649 were lower in NSCLC patients in comparison with the control group. In addition, the rs767649 AT genotype frequency in smoking controls was higher than in smoking NSCLC patients (OR = 0.44, 95% CI = 0.21-0.90, p = 0.024). No association was found between rs2910164 and rs767649 variants and stage or type of NSCLC.ConclusionOur finding suggests that miR-146a rs2910164 and miR-155 rs767649 polymorphisms may be considered as genetic risk factors for the susceptibility to NSCLC in the Iranian population. However, a larger multicenter study across Iran is needed to confirm these findings.

Dataset Information

A miR-SNP of the XPO5 gene is associated with advanced non-small-cell lung cancer.

Objectives

Materials and methods

Results

Conclusion

Publications

A miR-SNP of the XPO5 gene is associated with advanced non-small-cell lung cancer.

Similar Datasets

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