Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

ABSTRACT:

Background

Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.

Methods

We analysed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestory. To characterise allelic effects on each disorder, we applied a multinomial logistic regression procedure with model selection to identify the best-fitting model of relations between genotype

SUBMITTER: Cross-Disorder Group of the Psychiatric Genomics Consortium 

PROVIDER: S-EPMC3714010 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature