Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer.

ABSTRACT:

Background

Obesity and diabetes mellitus are associated with an increased risk of pancreatic cancer. These associations may be secondary to consequences of peripheral insulin resistance, pancreatic β-cell dysfunction, or hyperglycemia itself. Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic β-cell dysfunction.

Methods

This was a prospective, nested case-control study of 449 case patients and 982 control subjects with prediagnostic blood samples and no diabetes history from five prospective US cohorts followed through 2008. Two or three control subjects were matched to each case patient by year of birth, cohort, smoking, and fasting sta

SUBMITTER: Wolpin BM 

PROVIDER: S-EPMC3714020 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature