Benign breast disease, mammographic breast density, and the risk of breast cancer.

ABSTRACT:

Background

Benign breast disease and high breast density are prevalent, strong risk factors for breast cancer. Women with both risk factors may be at very high risk.

Methods

We included 42818 women participating in the Breast Cancer Surveillance Consortium who had no prior diagnosis of breast cancer and had undergone at least one benign breast biopsy and mammogram; 1359 women developed incident breast cancer in 6.1 years of follow-up (78.1% invasive, 21.9% ductal carcinoma in situ). We calculated hazard ratios (HRs) using Cox regression analysis. The referent group was women with nonproliferative changes and average density. All P values are two-sided.

Results

Benign breast disease and breast density were independently associated with breast cancer. The combination of

SUBMITTER: Tice JA 

PROVIDER: S-EPMC3714021 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature